Patrick P Michel Selected Research

annonacin

11/2008	Atypical parkinsonism in the Caribbean island of Guadeloupe: etiological role of the mitochondrial complex I inhibitor annonacin.
7/2007	Annonacin, a natural mitochondrial complex I inhibitor, causes tau pathology in cultured neurons.
1/2004	Annonacin, a lipophilic inhibitor of mitochondrial complex I, induces nigral and striatal neurodegeneration in rats: possible relevance for atypical parkinsonism in Guadeloupe.

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Patrick P Michel Research Topics

Disease

28	Parkinson Disease (Parkinson's Disease) 02/2024 - 09/2003
8	Neurodegenerative Diseases (Neurodegenerative Disease) 02/2024 - 11/2005
5	Parkinsonian Disorders (Parkinsonism) 01/2023 - 01/2002
3	Tauopathies 01/2021 - 11/2005
2	Synucleinopathies 01/2022 - 01/2021
2	Dementia (Dementias) 01/2021 - 11/2008
1	Astrocytoma (Pilocytic Astrocytoma) 10/2023
1	Inflammation (Inflammations) 01/2020
1	Brain Injuries (Brain Injury) 01/2017
1	Neuroinflammatory Diseases 05/2016
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2016
1	Hallucinations (Hallucination) 11/2008
1	Tremor (Tremors) 11/2008
1	Myoclonus (Nocturnal Myoclonus) 11/2008
1	REM Sleep Behavior Disorder 11/2008
1	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 11/2005
1	Alzheimer Disease (Alzheimer's Disease) 06/2005

Drug/Important Bio-Agent (IBA)

6	Dopamine (Intropin)FDA LinkGeneric 01/2022 - 12/2013
5	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 10/2023 - 11/2008
5	Neuroprotective AgentsIBA 10/2017 - 01/2013
3	SynucleinsIBA 02/2024 - 11/2018
3	Levodopa (L Dopa)FDA LinkGeneric 12/2022 - 01/2002
3	Doxycycline (Periostat)FDA LinkGeneric 01/2021 - 05/2016
3	Proteins (Proteins, Gene)FDA Link 01/2021 - 01/2016
3	annonacinIBA 11/2008 - 01/2004
2	NeurotoxinsIBA 10/2023 - 12/2013
2	Toll-Like Receptor 4IBA 01/2023 - 01/2013
2	alpha-SynucleinIBA 01/2021 - 11/2005
2	Glutamic Acid (Glutamate)FDA Link 01/2020 - 11/2018
2	CytokinesIBA 01/2020 - 01/2013
2	Adenosine Triphosphate (ATP)IBA 12/2013 - 07/2007
2	AcetogeninsIBA 07/2007 - 01/2004
1	NRH - quinone oxidoreductase2IBA 10/2023
1	N- (2- (2- methoxy- 6H- dipyrido(2,3- a- 3,2- e)pyrrolizin- 11- yl)ethyl)- 2- furamideIBA 10/2023
1	PesticidesIBA 01/2023
1	Chlordecone (Kepone)IBA 01/2023
1	Oxidopamine (6 Hydroxydopamine)IBA 12/2022
1	catechol (pyrocatechol)IBA 12/2022
1	1,2,3,4-tetrahydroisoquinolineIBA 12/2022
1	Tolcapone (Tasmar)FDA Link 12/2022
1	TransferasesIBA 12/2022
1	2',3'-dideoxy-5-methylcytidineIBA 01/2022
1	Glucose (Dextrose)FDA LinkGeneric 01/2020
1	CannabidiolIBA 01/2020
1	EnzymesIBA 01/2019
1	GhrelinIBA 12/2017
1	XenonIBA 01/2017
1	LipopolysaccharidesIBA 05/2016
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2016
1	CalciumIBA 01/2016
1	OrexinsIBA 01/2015
1	Chaperonin 60IBA 05/2014
1	Probenecid (Benemid)FDA LinkGeneric 12/2013
1	Uricosuric AgentsIBA 12/2013
1	LactoferrinIBA 12/2013
1	IronIBA 12/2013
1	Glycoproteins (Glycoprotein)IBA 12/2013
1	ApaminIBA 01/2013
1	Bee Venoms (Bee Venom)IBA 01/2013
1	Nicotine FDA Link 08/2011
1	purineIBA 05/2009
1	Uric Acid (Urate)IBA 05/2009
1	Caffeine (No Doz)FDA LinkGeneric 10/2008
1	Carisoprodol (Soma)FDA LinkGeneric 07/2007
1	neuromelaninIBA 01/2007
1	tau Proteins (tau Protein)IBA 11/2005
1	RotenoneIBA 11/2005
1	Cholinergic Agents (Cholinergics)IBA 06/2005
1	Herbal TeasIBA 01/2004
1	Proteasome Endopeptidase Complex (Proteasome)IBA 09/2003